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Redirecting an organism’s metabolism towards novel products raises several design issues. What is the impact of the new pathway on the cell’s energy and redox metabolism? Can the precursor and coenzyme requirements be satisfied? Should some parts of the metabolic network be blocked off to ensure the most efficient routes to the product are favoured? Answering these questions needs tools that can compute and compare feasible routes through the cell’s metabolic network, as well as methods for defining and representing the metabolic network in a way the tools can use. This is the domain of structural analysis of metabolism, and techniques such as elementary modes analysis and flux balance analysis. This combined theoretical and practical course will explain the theory behind these techniques and give hands-on experience of calculating feasible and optimal routes through metabolic networks. It will be presented by Mark Poolman, his colleagues in the Cell Systems Modelling Group and others.
Free participation, accommodation (for non-local delegates) and meals for 4 days and 4 nights
Arrival is Monday 2 May (evening); the workshop takes place Tuesday 3 May (morning) – Friday 6 May (lunchtime).
At the Mercure Hotel, 2 George Street, Lace Market, Nottingham NG1 3BP, UK.
Register by THURSDAY 14 APRIL 2022.
Successful applicants will be notified by FRIDAY 22 APRIL 2022.